Penicillin V Potassium

Brand names: Beepen VK, Betapen-VK, Biotic-V Powder, Bopen V-K, Ledercillin VK, Penpar VK, Pen-V, Pen*Vee K, Pfizerpen VK, Robicillin-VK, Uticiiiin VK, V-cillin K, Veetids

Penicillin V Potassium is an antibiotic. It is used to treat a variety of bacterial infections. 

Quick Facts About Penicillin V


Used to treat a variety of infections including: dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections. Is ineffective against fungi, viruses, and parasites.

Penicillin V Dosage

Take on a full or empty stomach; complete entire course of treatment prescribed. Use spoon from pharmacy for oral solution, shake well before using.

  • Usual adult dose: for mild to moderately severe strep infections of the upper respiratory tract and skin, and scarlet fever — 125 to 250 milligrams every 6 to 8 hours for 10 days. For mild to moderately severe pneumococcal infections of the respiratory tract, including middle ear infections — 250 milligrams every 6 hours until fever subsides for at least 2 days. For mild staph infections of the skin — 250 milligrams every 6 to 8 hours. For mild to moderately severe gum infections known as Vincent’s gingivitis — 250 milligrams every 6 to 8 hours. To prevent rheumatic fever and lor chorea — 125 milligrams taken 2 times per day on a continuing basis. To prevent bacterial endocarditis (inflammation of heart membrane) in people with heart disease who are undergoing dental or surgical procedures — orally — 2 grams 1/2 hour to 1 hour before surgery, then 500 milligrams every 6 hours for 8 doses.
  • Usual child dose: for children 12 and over — same as adult dose. For children under 12 — not generally prescribed.
  • Missed dose: for 2 doses per day — take as soon as possible, take next dose 5 to 6 hours later, then go back to regular schedule. For 3 or more doses per day — take as soon as possible, take next dose 2 to 4 hours later, then go back to regular schedule.

Penicillin V Side Effects

Overdose symptoms:

diarrhea, nausea, vomiting. If you suspect an overdose, immediately seek medical attention.

Side effects: anemia, black or hairy tongue, diarrhea, fever, hives, nausea, skin eruptions, stomach upset or pain, swelling in throat, vomiting.

No known less common or rare Penicillin V side effects.


Inform your doctor before combining Penicillin V with:

chloramphenicol (Chloromycetin), cholestyramine (Questran), colestipol (Colestid), oral contraceptives, tetracyclines such as Achromycin V.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children under 12 years. Follow doctor’s instructions carefully for children 12 years and older.

  • Should not use if allergic to penicillin or cephalosporin antibiotics in any form; may experience severe reaction.
  • If you experience any allergic reaction, stop taking medication and immediately contact your doctor.
  • If you have rashes, hives, hay fever, asthma, colitis, diabetes, or liver or kidney disease, inform your doctor before taking Penicillin V.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Penicillin V side effects, please contact your healthcare provider