Generic name: Famotidine.

Pepcid is an antiulcer agent. It reduces stomach acid by blocking the effects of histamine in the stomach. 

Quick Facts About Pepcid


Used to treat active duodenal ulcer (in the upper intestine) for 4 to 8 weeks, and active benign gastric ulcer (in the stomach) for 6 to 8 hours. Also used to treat gastroesophageal reflux disease (GERD), condition in which acid contents of the stomach flow back into the esophagus and inflame it. Also used to treat diseases which result in excessive amounts of acid in the stomach, such as Zollinger-Ellison syndrome.

Pepcid Dosage

Shake suspension 5 to 10 seconds before use. May take several days for medication to relieve stomach pain. Can use antacids, but not within 1 hour of a dose of Pepcid. Must take full treatment to cure your ulcer.

  • Usual adult dose: for duodenal ulcer — 40 milligrams or 5 milliliters (1 teaspoonful) once per day at bed-time. Should see results in 4 weeks. Do not take for longer than 6 to 8 weeks. For benign gastric ulcer — 40 milligrams or 5 milliliters (1 teaspoonful) once per day at bedtime. For GERD — 20 milligrams or 2.5 milliliters (1/2 teaspoonful) 2 times per day for up to 6 weeks. For esophagus inflammation due to GERD — 20 or 40 milligrams or 2.5 to 5 milliliters twice per day for up to 12 weeks. For excess acid conditions — 20 milligrams every 6 hours. For people with kidney disease — doctor will adjust dosage.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Pepcid Side Effects

Overdose symptoms:

no specific information availabie. If you suspect an overdose, immediately seek medical attention.

More common side effects: headache.

Less common or rare  Pepcid side effects: abdominal discomfort; acne; agitation; altered taste; anxiety; changes in behavior; confusion; constipation; decreased sex drive; depression; diarrhea; difficulty sleeping; dizziness; dry mouth; dry skin; facial swelling due to fluid retention; fatigue; fever; flushing; grand mal seizures; hair loss; hallucinations; hives; impotence; irregular heartbeat; itching; loss of appetite; muscle, bone, or joint pain; nausea; pounding heartbeat; prickling, tingling, or pins and needles; rash; ringing in ears; severe allergic reaction; sleepiness; vomiting; weakness; wheezing; yellow eyes and skin.


Inform your doctor before combining Pepcid with:

itraconazole (Sporanox), ketoconazole (Nizoral), pancrelipase (Pancrease MT), pentoxifylline (Trental), probenecid (Benemid).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Should not take if sensitive to or allergic to Pepcid.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Pepcid side effects, please contact your healthcare provider