Generic name: Dipyridamole.

Other brand names: Pyridamole.

Persantine is an anti-platelet agent and vasodilator. It prevents the aggregation of platelets and relieves chest pain by dilating heart blood vessels, thereby providing more oxygen to the heart. 

Quick Facts About Persantine


Used to reduce blood clots in people who have had heart valve surgery, in combination with blood-thinning medications. Also used with aspirin to reduce damage from heart attack and prevent recurrence, to treat angina (crushing chest pain), and to prevent complications during heart bypass surgery.

Persantine Dosage

Take on empty stomach with a full glass of water. May take with food or milk to avoid stomach upset Do not change brands without consulting your doctor.

  • Usual adult dose: 75 to 100 milligrams taken 4 times per day.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: take as soon as possible, unless within 4 hours of next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Persantine Side Effects

Overdose symptoms:

low blood pressure. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal distress, dizziness.

Less common or rare Persantine side effects: angina (crushing chest pain), diarrhea, feeling flushed, headache, itching, liver problems, skin rash, vomiting.


Inform your doctor before combining Persantine with:

blood thinners such as Coumadin, indomethacin (Indocin), ticlopidine (Ticlid), valproic acid (Depakene). To avoid increased bleeding, take only the amount of aspirin prescribed by the same doctor prescribing Persantine. If you need medication for pain or fever, do not take extra aspirin without consulting the doctor who prescribed Persantine.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children under 12 years.

  • Use carefully if you have low blood pressure.
  • Inform your doctor or dentist in the event of a medical emergency or surgery that you are taking Persantine.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Persantine side effects, please contact your healthcare provider