Phospholine Iodide

Generic name: Echothiophate iodide.

Phospholine Iodide is a miotic. It reduces fluid pressure in the eye by constricting the pupil and increasing the flow of fluid out of the eye. 

Quick Facts About Phospholine Iodide


Used to treat chronic open-angle glaucoma. Also used to treat secondary glaucoma, subacute or chronic angle – dosure glaucoma either after or in the absence of surgery, and in children with accommodative esotropia (cross-eye).

Phospholine Iodide Dosage

Use exactly as directed by your doctor. If eye problems return after 1 or 2 years of treatment, your doctor may suggest surgery.

  • Usual adult dose: for glaucoma — 0.03 percent solution used 2 times per day in the morning and at bedtime.
  • Usual child dose: for accommodative esotropia — 1 drop of 0.125 percent solution at bedtime for 2 or 3 weeks. May be reduced to 0.125 solution every other day or 0.06 percent solution every day.
  • Missed dose: for 1 dose every other day — apply as soon as possible if it is the scheduled day. Otherwise, do not apply missed dose; go back to regular schedule. For 1 dose per day — apply as soon as possible unless it is the next day. Otherwise, do not apply missed dose, go back to regular schedule. For 2 doses per day — apply as soon as possible unless almost time for next dose. In that case, do not apply missed dose, go back to regular schedule. Do not double doses.

Phospholine Iodide Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

Side effects: ache above the eyes, blurred vision, burning or clouded eye lens, cyst formation, decreased pupil size, decreased visual sharpness, excess tears, eye pain, heart irregularities, increased eye pressure, inflamed iris, lid muscle twitching, nearsightedness, red eyes, stinging.

No known less common or rare Phospholine Iodide side effects.


Inform your doctor before combining Phospholine Iodide with:

Enlon, Mestinon, or Tensilon, which are used to treat myasthenia gravis (muscle weakness that affects muscles in the eyes, face, limbs, and throat).

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. No information available about the effects of Phospholine Iodide during pregnancy; should not be used if breastfeeding.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • May cause vision problems; use caution if driving at night or when working in poor light
  • Stop taking and immediately contact your doctor if you experience: breathing difficulties, diarrhea, inability to hold urine, muscle weakness, profuse sweating or salivation.
  • Doctor should perform regular check-ups if you are taking this medication for an extended period.
  • Pesticides such as Sevin and Trolene may increase side effects; use extra precautions if working with these chemicals — wear mask over mouth and nose, wash and change clothing frequently, and wash hands often.
  • Should not use if you have eye inflammation or angle-dosure glaucoma, or if sensitive to or allergic to this medication.
  • Use with caution if you have or ever had: bronchial asthma, detached retina, epilepsy, extreme low blood pressure, Parkinson’s disease, peptic ulcer, recent heart attack, slow heartbeat, stomach or intestinal problems.
  • Immediately contact your doctor if you notice heart problems.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Phospholine Iodide side effects, please contact your healthcare provider