Generic name: Felodipine.

Plendil is a calcium channel blocker. It increases the amount of oxygen that reaches the heart muscle.

Quick Facts About Plendil


Used to treat high blood pressure.

Plendil Dosage

Can take with or without food. Swallow tablet whole, never crush or chew. Continue taking if symptoms disappear; however, may take several weeks before you observe the full effects. If you miss a dose, or do not take regularly, blood pressure may increase.

  • Usual adult dose: 5 milligrams once per day initially, then 5 to 10 milligrams, up to 20 milligrams once per day maximum for usual dose. For seniors or those with liver problems — maximum daily dose is 10 milligrams.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Plendil Side Effects

Overdose symptoms:

severely low blood pressure, slow heartbeat. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, back pain, chest pain, constipation, cough, diarrhea, dizziness, flushing, headache, indigestion, muscle cramps, nausea, pounding heartbeat, rash, runny nose, sore throat, swelling of legs and feet, tingling sensation, upper respiratory infection, weakness.

Less common or rare Plendil side effects: anemia, angina pectoris (crushing chest pain), ankle pain, anxiety disorders, arm pain, arthritis, blurred vision, bronchitis, bruising, decreased sex drive, depression, difficulty sleeping, dry mouth, excessive nighttime urination, gas, generalized muscle pain, heart attack, hip pain, hives, impotence, inflammation of gums, inflammation of the nose, irregular heartbeat, irritability, itching, joint pain, knee pain, leg pain, low blood pressure, neck pain, nervousness, nosebleeds, painful or difficult urination, rapid heartbeat, respiratory infections, ringing in ears, shortness of breath, shoulder pain, sinus inflammation, sleepiness, sneezing, stomach and intestinal pain, tremor, unusual redness of the skin, urgent urination, vomiting, warm sensation.


Inform your doctor before combining Plendil with:

beta-blockers such as Lopressor, Inderal, and Tenormin; cimetidine (Tagamet); digoxin (Lanoxin); epilepsy medications such as Tegretol and Dilantin; erythromycin (PCE, Eryc); phenobarbital; theophylline (Theo-Dur).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Birth defects have appeared in animal studies. May appear in breast milk; could affect a nursing infant

Seniors are prescribed lower doses, and should have blood pressure monitored while doctor is adjusting dosage.

Not generally prescribed for children.

  • If sensitive to or allergic to this or other calcium channel blockers, should not take.
  • May cause low blood pressure. Immediately notify your doctor if you experience light-headedness, heart racing, or chest pain.
  • Use with caution if you have congestive heart failure, especially if taking a beta-blocker such as Inderal or Tenormin.
  • May experience swelling of legs and feet in the first 2 to 3 weeks of starting medication.
  • To avoid swollen and sore gums, practice good dental hygiene.
  • In the case of liver disease, doctor will monitor blood pressure.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Plendil side effects, please contact your healthcare provider