Generic name: Mefenamic acid.

Ponstel is a nonsteroidal anti-inflammatory analgesic. It blocks the production of body chemicals called prostaglandins, which trigger pain.

Quick Facts About Ponstel


Used to treat moderate pain (for not more than 7 days) and menstrual pain.

Ponstel Dosage

To avoid stomach upset, take with food, an antacid, or milk. Take exactly as prescribed.

  • Usual adult dose: for moderate pain — 500 milligrams followed by 250 milligrams every 6 hours if needed, for 1 week. For menstrual pain — 500 milligrams followed by 250 milligrams every 6 hours for 2 to 3 days.
  • Usual child dose: children 14 years and older are prescribed adult dose. Not generally prescribed for children under 14 years.
  • Missed dose: if taking on a regular schedule — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Ponstel Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, diarrhea, nausea, stomach and intestinal upset, vomiting.

Less common or rare Ponstel side effects: anemia, blurred vision, blood in urine, changes in liver function, constipation, difficult or painful urination, dizziness, drowsiness, ear pain, eye irritation, facial swelling due to fluid retention, fluttery or throbbing heartbeat, gas, headache, heartburn, hives, inability tc sleep, increased need for insulin as a diabetic, kidney failure, labored breathing, loss of appetite, loss of color vision, nervousness, rash, red or purple skin spots, sweating, ulcers and internal bleeding.


Inform your doctor before combining Ponstel with:

aspirin, blood thinners such as Coumadin, diuretic such as Lasix and HydroDIURIL, lithium (Lithonate), methotrexate.

No known food/other substance interactions. 

Special Cautions

Should not be used during latter stages of pregnancy, as it affects heart and blood vessels of fetus. If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children over 14 years.

  • Do not take if you have stomach ulcerations or frequently recurring inflammation of stomach or intestines.
  • Do not take if sensitive to or allergic to Ponstel. Should not take if you have had asthma attacks, hay fever, or hives caused by aspirin or other nonsteroidal anti-inflammatory medications such as Motrin or Nuprin.
  • Stop taking and immediately contact your doctor if you experience rash, diarrhea, or other stomach problems.
  • Doctor should monitor for ulcers or internal bleeding if you take Ponstel regularly.
  • Should use with caution if you have kidney disease, heart failure, or liver disease.
  • May prolong bleeding time; if using a blood-thinning medication, use Ponstel with caution.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Ponstel side effects, please contact your healthcare provider