Generic name: Repaglinide.

Prandin is a diabetes drug classified as a meglitinide. Unlike sulfonylureas, it lowers blood sugar by stimulating the pancreas to produce more insulin when blood glucose rises as a result of eating.

Quick Facts About Prandin


Used to treat Type II (non-insulin-dependent) diabetes when diet and exercise alone fail to contra abnormally high blood sugar levels.

Prandin Dosage

Take exactly as prescribed. Take orally 15 minutes before each main meal. Should not be taken without a meal; and if an extra meal is added during the day, a dose is added for that meal. Always carry a food product containing sugar to counter low blood suga-symptoms. Carefully follow dietary and exercise instructions from your doctor.

  • Usual adult dose: initially — 0.5 to 2 milligrams 15 minutes before each main meal. Doctor may increase dose up to no more than 4 milligrams.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible, unless almos: time for next dose. In that case, do not take misse: dose; go back to regular schedule. Do not doubn doses.

Prandin Side Effects

Overdose symptoms:

low blood sugar (hypoglycemia) — blurred vision, cold sweats, depressed mood, dizziness, drowsiness, fatigue, headache, hunger, inability to concentrate, irritability, nausea, nervousness, personality changes, rapid heartbeat, restlessness, sleep disturbances, slurred speech, sweating, tingling, tremor, unsteady movements. More severe symptoms — coma, disorientation, pale skin, perspiration, rash over entire body, seizures, shortness of breath, shallow breathing or wheezing. If you suspect an overdose, immediately seek medical attention.

More common side effects: cold- and flu-like symptoms, hyperglycemia, hypoglycemia, respiratory problems.

Less common Prandin side effects: back pain, diarrhea, joint ache. Rare side effects: allergic reaction, low blood cell or platelet count. Rare side effects should disappear in time.


Inform your doctor before combining Prandin with:

antibacterials such as clarithromycin (Biaxin) and erythromycin; anticonvulsants such as carbamazepine (Tegretol) and phenobarbital (Nembutal); aspirin and other salicylate medications; azole antifungals such as ketoconazole (Nizoral); beta-blockers such as Tenormin, Inderal, and Lopressor; chloramphenicol (Chloromycetin); MAO inhibitors (Nardil or Parnate); NSAIDs such as ibuprofen, indomethacin, naproxen; probenecid (Benemid); rifampin (Rifadin); sulfa drugs such as Bactrim DS and Septra DS; troglitazone (Rezulin).

Use alcohol with care; excessive use can cause low blood sugar. Use caution when combining with large doses of vitamin C, citrus fruits, and other foods that increase acidity in urine. Avoid nonprescription cough, cold, and allergy remedies unless otherwise directed by your doctor. 

Special Cautions

May cause birth defects. If pregnant or planning to become pregnant, inform your doctor immediately. Your doctor may prescribe insulin therapy, which is safe during pregnancy. Appears in breast milk; could cause low blood sugar in nursing infant. Strictly adhere to dietary and prescribing instructions.

Seniors may be more sensitive to Prandin; should be closely monitored by doctor.

Not prescribed for children.

  • Prandin is not an oral form of insulin and cannot be used in place of insulin.
  • Do not take to correct the following symptoms: excessive thirst, nausea, fatigue, and fruity breath. You may have diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin), which should be treated with insulin.
  • Inform your doctor if you have a heart condition. Mat lead to more heart problems than diet treatment alone or treatment with diet and insulin only.
  • Inform your doctor before taking if you have a history of serious liver, kidney, or endocrine disease
  • Check blood and urine regularly for abnormally high-sugar (glucose) levels. Effectiveness of any oral antidiabetic, including Prandin, may decrease with time due to diminished responsiveness to the medication or worsening of the diabetes.
  • For people with well-controlled diabetes; stress such as injury, infection, surgery, or fever may trigger a loss of control. Your doctor may recommend adding insulin to your Prandin treatment or replacing your Prandin treatment temporarily with insulin.
  • Wear ID stating you are diabetic and whether or not you are insulin-dependent.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Prandin side effects, please contact your healthcare provider