Generic name: Conjugated estrogens.

Other brand names: Estracon, Progens Tabs.

Premarin is an estrogen replacement/antineoplastic/antiosteoporotic. It mimics the action of naturally produced estrogen, inhibits the growth of hormone-sensitive tissue in some cancers, enhances calcium and phosphate retention, and limits bone decalcification.

Quick Facts About Premarin


Used to reduce symptoms of menopause. Also used for teenagers who do not mature at usual rate, to relieve symptoms of certain cancers, and to relieve dry, itchy external genitals and vaginal irritation. Prescribed along with diet, calcium supplements, and exercise to prevent osteoporosis.

Premarin Dosage

Take exactly as prescribed. Do not share prescription.

  • Usual adult dose: for menopause symptoms — 0.3 to 1.25 milligrams per day. For vaginitis — 0.3 to 1.25 milligrams or more per day. For low estrogen levels due to 1 reduced ovary function — 2.5 to 7.5 milligrams per day, in divided doses for 20 days, followed by a rest period of 10 days. For ovary removal or failure — 1.25 milligrams per day, 3 weeks on and 1 week off Premarin. For osteoporosis — 0.625 milligram per day; 3 weeks on and 1 week off. For breast cancer (women and men) — 10 milligrams taken 3 times per day for at least 3 months. For relief of symptoms of advanced androgen-dependent prostate cancer — 1.25 to 2.5 milligrams taken 3 times per day. Vaginal cream — for atrophic vaginitis or severe itching — 2 to 4 grams (1/2 applicator) per day inserted into vagina or lowest dose possible, used for 3 weeks and off for 1 week. Women with uterus intact should be monitored for endometrial cancer.
  • Usual child dose: follow doctor’s individualized dose.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Premarin Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

Side effects: abdominal cramps, abnormal vaginal bleeding, bloating, breast swelling and tenderness, depression, dizziness, enlargement of benign tumors in uterus, fluid retention, gallbladder disease, hair loss from scalp, increased body hair, intolerance to contact lenses, migraine headache, nausea, vomiting, sex-drive changes, skin darkening (especially on the face), skin rash or redness, swelling of wrists and ankles, vaginal yeast infection, weight gain or loss, yellow eyes and skin.

No less common  or rare Premarin side effects.


Inform your doctor before combining Premarin with:

barbiturates such as phenobarbital; blood thinners such as Coumadin; epilepsy medications such as Dilantin; major tranquilizers such as Thorazine; oral diabetic medications such as Micronase; rifampin (Rifadin); thyroid preparations such as Synthroid; tricyclic antidepressants such as Elavil and Tofranil; vitamin C.

No known food/other substance interactions.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately, may harm fetus.

No special precautions apply to seniors.

Follow doctor’s individualized instructions for children.

  • Do not take if you have had an allergic or bad reaction to this medication, or undiagnosed vaginal bleeding.
  • Notify your doctor immediately if you experience: abdominal pain, tenderness, or swelling; unusual vaginal bleeding; coughing up blood; pain in chest or calves; severe headache; dizziness or faintness; sudden shortness of breath; vision changes; yellowing of skin.
  • Should not take Premarin if you have breast cancer or other estrogen-dependent cancer unless your doctor makes an exception.
  • Women taking this medication after menopause are at higher risk for gallbladder disease.
  • Risk of blood clots increases with Premarin therapy.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Premarin side effects, please contact your healthcare provider