Generic name: Omeprazole.

Prilosec is a gastric acid secretion inhibitor. It inhibits the production of gastric acid.

Quick Facts About Prilosec


Used to treat active duodenal ulcer, gastroesophageal reflux disease (GERD—backflow of acid stomach contents), and severe erosive esophagitis on a short-term (4 to 8 weeks) basis. Also used to treat Zollinger-Ellison syndrome (too much stomach acid secretion), multiple endocrine adenomas (benign tumors), and systemic mastocytosis (cancerous cells), on a long-term basis. Additionally, used to treat inflammation of the esophagus and gastric ulcers.

Prilosec Dosage

Take before meals for best results. May take with ar antacid. Swallow capsules whole; not to be crushed or chewed. May take several days to see results must adhere to dosage schedule.

  • Usual adult dose: for short-term treatment of active duodenal ulcer — 20 milligrams once per day. For severe erosive esophagitis or GERD — 20 milligrams per day for 4 to 8 weeks. For pathological hypersecretory conditions — 60 milligrams once per day. If taking more than 80 milligrams per day, doctor will divide into smaller doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Prilosec Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, diarrhea, headache, nausea, vomiting.

Less common or rare Prilosec side effects: abdominal swelling, abnormal dreams, aggression, anemia, anxiety, apathy, back pain, breast development in males, blood in urine, changes in liver function, chest pain, confusion, constipation, cough, depression, difficulty sleeping, discolored feces, dizziness, dry mouth, dry skin, fatigue, fever, fluid retention and swelling, flut-tery heartbeat, frequent urination, gas, general feeling of illness, hair loss, hallucinations, hepatitis, high blood pressure, hives, irritable colon, itching, joint and leg pain, loss of appetite, low blood sugar, muscle cramps and pain, nervousness, nosebleeds, pain, pain in testicles, rapid heartbeat, rash, ringing in ears, skin inflammation, sleepiness, slow heartbeat, taste distortion, tingling or pins and needles, throat pain, tremors, upper respiratory infection, urinary tract infection, vertigo, weakness, weight gain, yellow eyes and skin.


Inform your doctor before combining Prilosec with:

ampicillin-containing medications such as Spectrobid, cyclosporine (Sandimmune), diazepam (Valium), disulfiram (Antabuse), iron (Feosol), ketoconazole (Nizoral), phenytoin (Dilantin), warfarin (Coumadin).

Avoid excessive amounts of caffeine during Prilosec therapy.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Not for long-term use after ulcer has healed. Safety of prolonged use has yet to be established.
  • If sensitive to or allergic to this medication, should not take.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Prilosec side effects, please contact your healthcare provider