Procan SR

Generic name: Procainamide hydrochloride

Other brand names: Promine, Pronestyl-SR.

Procan SR is an anti-arrhythmic. It corrects irregular Heartbeats by altering nerve impulses within the heart to achieve a more normal rhythm. 

Quick Facts About Procan SR


Used to treat severe irregular heartbeats (arrhythmias), either tachycardia (too fast) or bradycardia (too slow).

Procan SR Dosage

Take prescribed amount only; never increase dosage. Swallow tablet whole; should not chew or crush. Adhere to schedule; skipping or missing doses or changing intervals may cause condition to worsen and may be dangerous.

  • Usual adult dose: doses and intervals are determined based on your doctor’s assessment of your heart disease, age, and kidney functioning. Younger people with normal kidney function — total daily dose of 50 milligrams per 2.2 pounds of body weight, divided into smaller doses and taken every 6 hours. People over age 50 or those with reduced kidney, liver, or heart function — prescribed lower doses with longer intervals between doses.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, if within 4 hours of scheduled dose. Otherwise, do not take missed dose, go back to regular schedule. Do not double doses.

Procan SR Side Effects

Overdose symptoms:

changes in heart function and heartbeat. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain; bitter taste; diarrhea; loss of appetite; nausea; symptoms similar to lupus (joint pain or inflammation, abdominal or chest pain, fever, chills, muscle pain, skin lesions); vomiting.

Less common Procan SR side effects: depression, dizziness, fluid retention, flushing, giddiness, hallucinations, hives, itching, rash, weakness. Rare side effects: anemia, changes in blood counts, low blood pressure.


Inform your doctor before combining Procan SR with:

anti-arrhythmic medications such as quinidine (Quinidex), propranolol (Inderal), and mexiletine (Mexitil); lidocaine; medications that ease muscle spasms such as benztropine (Cogentin) and trihexyphenidyl (Artane); neuromuscular blocking agents such as succinylcholine (Anectine).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant inforrr your doctor immediately. Appears in breast milk, could affect a nursing infant.

People over age 50 are prescribed lower doses.

Not generally prescribed for children.

  • Within first 3 months of therapy can cause serious blood disorders. Doctor will order blood count weekly for the first 12 weeks of therapy and then careful monitoring.
  • Immediately contact your doctor if you experience: joint or muscle pain, dark urine, yellowing skin or eyes, muscular weakness, chest or abdominal pain, appetite loss, diarrhea, hallucinations, dizziness, depression, wheezing, cough, easy bruising or bleeding, tremors, palpitations, rash, soreness or ulcers in mouth, sore throat, fever, or chills.
  • Doctor should not prescribe if you have lupus erythematosus or heartbeat irregularity known as “torsade de pointes”.
  • Doctor will closely monitor you if you have had: kidney or liver disease, or myasthenia gravis (disease causing muscle weakness, especially in face and neck).
  • Should not take if you have complete or incomplete heart block without a pacemaker, or if you have had an allergic reaction to procaine or similar local anesthetics, or aspirin.
  • Use with caution if you have ever had congestive heart failure or other heart disease.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Procan SR side effects, please contact your healthcare provider