Generic name: Cisapride.

Propulsid is an anti-heartburn medication. It prevents reflux of gastric contents into the esophagus by restoring the normal anti-reflux mechanism of the esophagus. 

Quick Facts About PropulsidPropulsid


Used to treat nighttime heartburn in the case of gastroesophageal reflux disease (GERD — back flow of stomach contents into esophagus).

Propulsid Dosage

Take 15 minutes prior to meals and at bedtime. Take exactly as prescribed, even if symptoms disappear.

  • Usual adult dose: tablet — one 10-milligram tablet 4 times per day. Doctor may increase dosage up to 20 milligrams 4 times per day. Oral suspension — 10 milliliters 4 times per day. Doctor may increase dosage up to 20 milliliters per day.
  • Usual child dose: Not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Propulsid Side Effects

Overdose symptoms:

frequent urination or bowel movements, gas, gurgling and rumbling stomach, retching. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, bloating, constipation, diarrhea, headache, inflamed nasal passages and sinuses, nausea, pain, upper respiratory and viral infections.

Less common Propulsid side effects: abnormal vision, anxiety, back pain, chest pain, coughing, depression, dehydration, dizziness, fatigue, fever, frequent urination, indigestion, insomnia, itching, inflammation of the vagina, joint pain, muscle pain, nervousness, rash, sore throat, urinary tract infection, vomiting.


Inform your doctor before combining Propulsid with:

antispasmatics such as Bentyl and Cogentin; cimetidine (Tagamet); clarithromycin (Biaxin); erythromycin (E-Mycin and Eryc); fluconazole (Diflucan); itraconazole (Sporanox); ketoconazole (Nizoral); miconazole (Monistat IV); ranitidine (Zantac); tranquilizers such as Librium, Valium, and Xanax; troleandomycin (TAO); warfarin (Coumadin).

May increase the effects of alcohol; do not drink while taking Propulsid.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Seniors may experience more frequent and severe side effects than younger patients.

Not prescribed for children.

  • Some medications could be dangerous if combined with Propulsid. Do not use this drug if you are taking Nizoral, Sporanox, Monistat IV, TAO, Biaxin, erythromycin, or Difulcan.
  • Do not take if you have sensitivity or allergic reaction to cisapride or any of its derivatives.
  • Propulsid is used only for nighttime heartburn; not effective for daytime heartburn.
  • Avoid if you have obstruction, perforation, or hemorrhage of the stomach or small bowel that might be aggravated by increased stomach and small-bowel movement; or if you’ve had any heart trouble.
  • Do not combine Propulsid with alcoholic beverages or tranquilizers; may cause drowsiness

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Propulsid side effects, please contact your healthcare provider