Generic name: Metoclopramide hydrochloride.

Other brand names: Clopra, Maxolon, Octamide, Reclomide.

Reglan is a dopamine antagonist and anti-emetic. It acts on the brain’s vomiting center to control or prevent nausea and vomiting, and it stimulates stomach and intestinal movement. 

Quick Facts About Reglan


Used to treat diabetic gastroparesis, a condition in which the stomach does not contract. Also used to treat heartburn in the case of gastroesophageal reflux disease (GERD — backflow of stomach contents into esophagus). Also prescribed to prevent nausea and vomiting as a result of cancer chemotherapy and surgery.

Reglan Dosage

Take 30 minutes prior to meals. Therapy lasts for 4 to 12 weeks; beyond 12 weeks is not recommended. If you suffer from diabetic “lazy stomach” (gastric stasis) on a recurring basis, doctor may advise taking Reglan as it reoccurs.

  • Usual adult dose: for GERD — 10 to 15 milligrams taken up to 4 times per day, 30 minutes prior to meals and at bedtime. For intermittent symptoms — single dose of 20 milligrams per day. For gastric stasis — 10 milligrams 30 minutes prior to meals and at bedtime for 2 to 8 weeks. Seniors — 5 milligrams per dose for GERD.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Reglan Side Effects

Overdose symptoms:

disorientation, drowsiness, in-voluntary movements. If you suspect an overdose, immediately seek medical attention.

More common side effects: drowsiness, fatigue, lassitude, restlessness.

Less common or rare Reglan side effects: breast development in males, confusion, continual discharge of milk from breasts, depression, diarrhea, dizziness, fluia retention, frequent urination, hallucinations, headache, high or low blood pressure, high fever, hives, impotence, inability to hold urine, insomnia, menstrual irregularities, nausea, rapid or slow heartbeat rash, rigid muscles, slow movement, swollen tongue or throat, tremor, vision problems, wheezing, yellowed eyes and skin. May also cause Parkinson-like symptoms, including slow movements, rigidity, tremor, or a mask-like facial appearance. May cause tardive dyskinesia, with symptoms such as jerky or writhing involuntary movements, particularly of the tongue, face, mouth, or jaw; involuntary movements of the arms and legs; grimacing; tongue-thrusting; locking of jaw; rigid backward arching of the body; and loud or labored breathing. Also can cause intense restlessness, with symptoms such as anxiety, agitation, foot-tapping, pacing, inability to sit still, jitteriness, and insomnia.


Inform your doctor before combining Reglan with:

acetaminophen (Tylenol); antispasmodics such as Bentyl and Pro-Banthine; cimetidine (Tagamet); digoxin (Lanoxin); insulin; MAO inhibitors such as Nardil and Parnate; levodopa (Dopar or Sinemet); narcotic painkillers such as Percocet and Demerol; sleeping pills such as Dalmane, Halcion, and Restoril; tetracycline (Achromycin or Sumycin); tranquilizers such as Valium and Xanax. Insulin dosage schedule for diabetics may be adjusted during Reglan therapy.

Do not drink alcohol during Reglan therapy. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Seniors are prescribed lower doses.

Not generally prescribed for children.

  • Do not take if you have: sensitivity to or allergic reaction to Reglan; pheochromocytoma (nonmalignant tumor causing hypertension); epilepsy; or a medication that may cause side effects such as jerks, tremors, grimaces, other writhing movements.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • If you suffer from Parkinson’s disease, either avoid Reglan or use very cautiously.
  • May cause mild to severe depression; inform your doctor if you have a history of depression.
  • Avoid if you have obstruction, perforation, or hemorrhage of the stomach or small bowel that might be aggravated by increased stomach and small-bowel movement.
  • Use with caution if you have high blood pressure.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Reglan side effects, please contact your healthcare provider