Generic name: Delavirdine.

Rescriptor is a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV. It works by inhibiting the reverse transcriptase (RT) enzyme necessary for the reproduction of HIV in body cells. Used in combination with other anti-HIV drugs for people who do not respond to single-drug therapy.

Quick Facts About Rescriptor


Used to slow the progress of the human immunodeficiency virus (HIV), which can lead to acquired immunodeficiency syndrome (AIDS).

Rescriptor Dosage

Take exactly as prescribed, with or without food. Do not share Rescriptor, and do not increase prescribed dose. For maximum absorption, dissolve tablet dose in 3 ounces of water, wait a few minutes, stir, and consume promptly. If you have achlorhydria (absence of stomach acid), take with an acidic beverage such as orange or cranberry juice.

  • Usual adult dose: 400 milligrams 3 times per day.
  • Usual child dose: not generally prescribed for children under 16 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Rescriptor Side Effects

Overdose symptoms:

none reported; however, if you suspect an overdose, immediately seek medical attention.

More common side effects: headache, nausea, rash, tiredness.

Less common Rescriptor side effects: diarrhea, itching, liver irritation, vomiting. May also affect any other part of the body including: blood and lymph system, eyes, ears, and nose, gastrointestinal system, heart, lungs, muscles, bones, nervous system.


Taking Rescriptor with certain drugs could be dangerous or life-threatening. Do not combine with: antimicrobials such as clarithromycin (Biaxin), dapsone (Avlosulfon or DDS), and rifabutin (Mycobutin); benzodiazepine tranquilizers or sleeping medications; cisapride (Propulsid); ergot derivatives; quinidine (Quinalan and Quinidex); warfarin (Coumadin).

Inform your doctor before combining Rescriptor with:

AIDS drugs such as didanosine (Videx); antihistamines such as astemizole (Hismanal), cimetidine (Tagamet), ranitidine (Zantac), and terfenadine (Seldane); calcium channel blockers such as nifedipine (Procardia); enzyme inducers such as carbamazepine (Tegretol), phenobarbital (Donnatal), phenytoin (Dilantin), or rifampin (Rifadin or Rimactane); fluoxetine (Prozac); ketoconazole (Nizoral); protease inhibitors such as indinavir (Cridican) and saquinavir (Invirase).

Antacids should be taken at least 1 hour before or after Rescriptor dose.

Special Cautions

If pregnant or planning to become pregnant inform your doctor immediately. Do not breastfeed; HIV appears in breast milk and could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children.

  • Long-term effects of medication still are not known. Since the HIV virus remains in the body, risk is still present for complications, including opportunistic infections such as pneumonia, tuberculosis, and fungal infection. It is important to remain under the care of a doctor and go to follow-up appointments.
  • Inform your doctor before treatment if you have liver disease (especially cirrhosis) or diabetes.
  • Stop medication immediately and inform your doctor if you develop blisters, eye irritation, mouth sores, muscle or joint ache, rash with fever or severe rash, swelling.
  • Does not reduce risk of transmitting HIV to others through sexual contact or blood contamination. Always use condoms and never share needles or equipment for injections with other people.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Rescriptor side effects, please contact your healthcare provider