Ru-Tuss Tablets

Generic ingredients: Phenylephrine hydrochloride with phenylpropanolamine hydrochloride, chlorpheniramine maleate, Hyoscyamine sulfate, atropine sulfate, and scopolamine hydrobromide.

Other brand names: Allerest, Condrin-LA, Conex D.A., Contac 12-hour, Dehist, Demazin, Drize, Dura-Vent/A, Genamin, Myminic, Oragest T.D., Ornade, Resaid S.R., Rhinolar-Ex 12, Triaminic, Trind, Triphenyl.

Ru-Tuss is an antihistamine and decongestant combination. It works by blocking the effects of histamine, a body chemical that narrows air passages, reducing swelling and itching, and drying secretions.

Quick Facts About Ru-Tuss Tablets


Used to treat runny or stuffy nose, nasal drip, itching, watery eyes, and scratchy or itchy throat caused by allergies, colds, and other irritations of the sinus, nose, and upper respiratory tract.

Ru-Tuss Dosage

Take exactly as prescribed. Swallow tablets whole; do not crush or chew.

  • Usual adult dose: 1 tablet in the morning and 1 tablet in the evening.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Ru-Tuss Side Effects

Overdose symptoms:

coma, delirium, fever, rapid breathing, respiratory failure, stupor. If you suspect an overdose, immediately seek medical attention.

Antihistamine overdose may result in convulsions and death in children.

Side effects: allergic reactions (rash or hives), blood disorders, blurred vision, constipation, diarrhea, dilated pupils, dizziness, drowsiness, dry mouth, dry nose and other mucous membranes, exhaustion, faintness, frequent urination, giddiness, increased chest congestion, insomnia, itching, lack of coordination, loss of appetite, low blood pressure or high blood pressure, nausea, nervousness, painful or difficult urination, pounding heartbeat, rapid heartbeat, ringing in the ears, stomach upset, tightness in the chest, vision changes, vomiting.

No known less common or rare Ru-Tuss side effects.


Do not take Ru-Tuss while taking antidepressants such as Nardil and Parnate.

Inform your doctor before combining Ru-Tuss with:

sleep medications such as Halcion and Dalmane, or tranquilizers such as Xanax and Valium.

Do not drink alcohol when taking Ru-Tuss. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately; pregnant women should not use.

No special precautions apply to seniors.

Not generally prescribed for children under 12 years.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Avoid if you are sensitive to or allergic to antihistamines or the ingredients in Ru-Tuss, or if you have glaucoma or bronchial asthma.
  • Use with caution if you have bladder obstruction, high blood pressure, cardiovascular disease, or an overactive thyroid.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Ru-Tuss side effects, please contact your healthcare provider