Generic name: Terfenadine.

Other brand names: Seldane-D.

Seldane is an antihistamine. Antihistamines block the effects of histamine, a body chemical that causes swelling and itching.

Quick Facts About Seldane


Used to treat sneezing, runny nose, stuffiness, itching, and tearing eyes from hay fever.

Seldane Dosage

Take only when needed. Swallow tablets whole, not to be crushed or chewed. Do not increase dose unless under the direction of your doctor.

  • Usual adult dose: Seldane — 1 tablet (60 milligrams taken 2 times per day. Seldane-D — 1 tablet taken 2 times per day.
  • Usual child dose: not generally prescribed for children under 12 years.
  • Missed dose: if taking Seldane regularly — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Seldane Side Effects

Overdose symptoms:

changes in heartbeat, confu-sion, fainting, headache, irregular heartbeat, nausea, seizures. If you suspect an overdose, immediately seek medical attention.

More common side effects: Seldane — drowsiness, fatigue, headache, stomach and intestinal problems. Seldane-D — drowsiness; dry mouth, nose, and throat headache; insomnia; loss of appetite; nausea; nervousness.

Less common Seldane side effects: Seldane — confusion, cough, depression, dizziness, dry mouth, dry nose, dry throat, excessive or spontaneous milk flow, fainting, frequent urination, hair thinning or loss, hepatitis, hives, increased appetite, irregular heartbeat, insomnia, itching, low blood pressure, menstrual disorders and pain, nightmares, nosebleeds, palpitations, rapid heartbeat, seizures, sensitivity to light, severe allergic reaction, sore throat, sweating, tingling or pins and needles, tremor, vision changes, weakness, wheezing. Seldane-D — blurred vision, change in bowel habits, change in taste, confusion, cough, depression, disorientation, dizziness, excessive or spontaneous flow of milk, fatigue, flare-up of psoriasis, frequent urination, hair loss, hepatitis, hives, increased appetite, increased energy, increased physical activity, irregular heartbeat, irritability, itching, menstrual disorders, muscle twitches, nightmares, nosebleeds, palpitations, rapid heartbeat, rash, restlessness, seizures, sensitivity to light, severe allergic reaction, sore throat, stomach and intestinal upset, sweating, tingling or pins and needles, tremors, upper respiratory infection, vision problems, vomiting, weakness, wheezing.


Do not take Seldane with: clarithromycin (Biaxin), erythromycin (PCE or E-Mycin), itraconazole (Sporanox), ketoconazole (Nizoral), troleandomycin (Tao Capsules).

Inform your doctor before combining Seldane with:

amiodarone (Cordarone), astemizole (Hismanal), bepridil (Vascor), disopyramide (Norpace), probucol (Lorelco), procainamide (Pronestyl or Procan), quinidine (Quinaglute or Quinidex). Seldane-D may interact with: MAO inhibitors (Nardil or Parnate), mecamylamine (Inversine), methyldopa, reserpine (Diupres).

No known food/other substance interactions. 

Special Cautions

If pregnant or plan to become pregnant, inform your doctor immediately. Do not take if breastfeeding.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Do not take if sensitive to or allergic to this medication, or if you have liver disease.
  • Avoid Seldane if you have severe high blood pressure or heart disease.
  • Causes much less drowsiness than other antihistamines.
  • Use with caution if you have diabetes, glaucoma, or enlarged prostate.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Seldane side effects, please contact your healthcare provider