Generic ingredients: Serpasil (reserpine) with Apresoline (hydralazine hydrochloride) and Esidrix (hydrochlorotniazide).

Ser-Ap-Es is an antihypertensive. It improves blood flow throughout the body and helps the body eliminate urine, which lowers blood pressure.

Quick Facts About Ser-Ap-Es


Used to treat high blood pressure. It combines the blood pressure medications Serpasil and Apresoline with Esidrix, a thiazide diuretic.

Ser-Ap-Es Dosage

Take exactly as prescribed, even if symptoms disappear. Must keep to schedule, missing doses may worsen high blood pressure. May take several weeks to see effects of medication.

  • Usual adult dose: no more than 0.25 milligram per day (2.5 tablets). Dosage is determined on individual needs.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Ser-Ap-Es Side Effects

Overdose symptoms:

coma, confusion, constricted pupils, calf muscle cramps, decreased amounts of urine, diarrhea, dizziness, drowsiness, fatigue, flushing, headache, heart attack, inability to urinate, increased amounts of urine, increased salivation, irregular heartbeat, low blood pressure, low body temperature, nausea, rapid heartbeat, severe fluid loss, shock, slow heartbeat, slowed breathing, thirst, tingling or pins and needles, vomiting, weakness. If you suspect an overdose, immediately seek medical attention.

More common side effects: angina (crushing chest pain); anemia; anxiety; blockage in intestines; blood disorders; blurred vision; breast development in males; breast engorgement; change in potassium levels; chills; conjunctivitis (pinkeye); constipation; cramping (stomach and intestinal); deafness; decreased sex drive; depression; diarrhea; difficult or labored breathing; difficult or painful urination; disorientation; dizziness; dizziness when standing up; drowsiness; dry mouth; enlarged spleen; eye disorders; fainting; fever; fluid in the lungs; fluid retention; flushing; glaucoma; headache; hepatitis; high blood sugar; hives; impotence; inflammation of lungs; inflammation of pancreas; inflammation of salivary glands; irregular heartbeat; irritation of stomach; itching; joint pain; loss of appetite; low blood pressure; muscle aches; muscle cramps; muscle spasm; nasal congestion; nausea: nervousness; nightmares; nosebleeds; numbness; parkinsonism syndrome (tremors, muscle weakness, shuffling walk, stooped posture, drooling); pounding heartbeat; rapid heartbeat; rash; red or purple skir discoloration; respiratory distress; restlessness; skin peeling; skin sensitivity to light; slow heartbeat; sugar in the urine; teary eyes; tingling or pins and needles; tremors; vertigo; vision changes; vomiting; weakness; weight gain; yellow eyes and skin.

No known less common or rare Ser-Ap-Es side effects.


Inform your doctor before combining Ser-Ap-Es with:

acth (adrenal hormone); amphetamines such as Dexedrine; antidepressant MAO inhibitors such as Nardil and Parnate; central nervous system medications such as Cylert and Desoxyn; digitalis (Lanoxin); elavil; insulin; lithium (Eskalith); nonsteroidal anti-inflammatory medications such as Motrin; norepinephrine (Levophed); other high blood pressure medications such as Aldomet and Vasotec; quinidine (Quinidex); steroids such as Deltasone; sympathetic nervous system stimulants such as epinephrine, ephedrine, isoproterenol, metaraminol, tyramine, and phenylephrine.

No known food/other substance interactions.

Special Cautions

If pregnant or plan to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a. nursing infant.

No special precautions apply to seniors.

Not generally prescribed for children.

  • Do not take if sensitive to or allergic to this medication or sulfa medications. If you have a history of allergies or bronchial asthma, at higher risk for allergic reaction.
  • Avoid Ser-Ap-Es if being treated for depression.
  • Should not take if you have: an active peptic ulcer; ulcerative colitis (chronic inflammation of the large intestine and rectum); coronary artery disease; rheumatic heart disease; or if unable to urinate or are receiving electroshock therapy.
  • Notify your doctor or dentist prior to a medical emergency or surgery that you are taking Ser-Ap-Es.
  • Doctor may prescribe a potassium supplement or advise you to eat foods high in potassium (bananas and orange juice), as diuretics may cause your body to lose potassium.
  • May cause depression that can last several months after Ser-Ap-Es therapy. Immediately contact your doctor if you experience; despondency, waking early in the morning, loss of appetite, impotence, loss of self-esteem.
  • Use cautiously if you have gallstones.
  • May activate or aggravate symptoms of lupus erythematosus.
  • Doctor will monitor you if you have coronary artery, kidney, or liver disease.
  • May mask symptoms of low blood sugar or alter blood sugar levels. Inform your doctor if you are diabetic.
  • On rare occasions abnormal amounts of uric acid in the blood may occur, leading to an attack of gout.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Ser-Ap-Es side effects, please contact your healthcare provider