Generic name: Quetiapine.

Seroquel is an antipsychotic of a new chemical class. It works by increasing the levels of certain chemicals in the brain.

Quick Facts About Seroquel


Used to manage psychotic disorders.

Seroquel Dosage

Take with or without food, at the same time every day.

  • Usual adult dose:  initially — 25 to 50 milligrams once per day. Doctor will increase dose every 1 or 2 day-up to 150 to 750 milligrams once per day.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Seroquel Side Effects

Overdose symptoms:

none reported; however, if you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, appetite change, difficulty breathing or talking, dizziness, dry mouth, cold- or flu-like symptoms, headache, heart palpitations, low white blood cell count, runny nose, sore throat, spastic movements, sweating, swelling in arms and legs, tiredness, upset stomach, weight change.

Less common Seroquel side effects: acne, anemia, apathy, arthritis, asthma, attempt at suicide, blood clots, blood fat or blood sugar bowel-control problems, broken bones or bone pain, bruising, catatonic reactions, chills, confusion, contact cystitis, dermatitis, delusion, depersonalization, dehydration, diabetes, difficulty swallowing, eye and vision problems, eczema, electrocardiogram changes or changes in electrical impulses in heart, facial swelling, fungal infection, flushing, gas, general feeling of ill health, gum irritation or bleeding, hallucination, hemorrhoids, increased sex drive, impotence or abnormal ejaculation, increased white blood cell count, inflamed testicles, intolerance to alcohol, irregular pulse, itching, joint pain, leg cramps, loss of kidney function, loss of periodic bleeding, manic reactions, memory loss, migraine, mouth or skin sores, muscle spasm or weakness, neck or pelvic pain, nosebleed, oozing breast milk, paranoid feelings, pneumonia, poor blood flow to brain, rash, rectal bleeding, ringing in ears, salivation, seborrhea, slow heartbeat, stomach contents coming back up into throat or mouth, stomach irritation, stroke, stupor, sun sensitivity, taste changes, teeth grinding, temporary paralysis on one side of body, thirst, thyroid problems, tongue swelling, tooth decay, twitching, uncoordinated or uncontrollable movement, unusual dreams, unusual walking, unusually painful menstruation, urinary problems, vaginal discharge, infection, or irritation. Rare side effects: abdominal enlargement, abnormal accommodation to light changes, angina pain, bleeding in the brain, blood in stool or vomit changes in skin color, deafness, delirium, emotional upset euphoria, extremely low blood platelet count glaucoma, gout hand swelling, heart failure, hiccups, intestinal blockage, kidney failure, loss of red blood cells, low blood potassium, nerve pain, nighttime urination, pancreas inflammation, peeling rash, psoriasis, rapid and deep breathing, rapid heartbeat reduced sex drive, speechlessness, stuttering, sugar in urine, swollen breasts, tooth problems, vein irritation.


Inform your doctor before combining Seroquel with:

anticorvulsants such as barbiturates, carbamazepine (Tegretol), and phenytoin (Dilantin); antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); antiparkinsonians such as levodopa; erythromycin; lorazepam (Ativan); oral corticosteroids; other antipsychotics such as thioridazine (Mellaril); rifampin (Rifadin).

Do not combine alcohol with this medication; may intensify sedative effects of alcohol.

Special Cautions

Effects of Seroquel on pregnant women and nursing mothers not known. If pregnant, planning to become pregnant, or breastfeeding, inform your doctor immediately.

Seniors may be more sensitive to some side effects of medication and should monitor for dizziness, fainting, and tiredness. Doctor may prescribe lower dose or increase dose more gradually.

Not prescribed for children.

  • At risk for neuroleptic malignant syndrome (NMS), which may be fatal. Symptoms: extremely high body temperature, rigid muscles, mental changes, irregular pulse or blood pressure, rapid heartbeat, sweating, and changes in heart rhythm.
  • May impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Ask your doctor about the risk of tardive dyskinesia, a condition marked by involuntary muscle movements.
  • Use with caution if you have or had: Alzheimer’s disease; asthma; emphysema; glaucoma; heart, kidney, or liver disease; seizures; exposure to heat.
  • Increased risk of developing cataracts. Monitor with an eye exam every 6 months.
  • Doctor will recommend a thyroid supplement if low levels of thyroid hormone appear in blood.
  • May cause temporary liver inflammation, which usually subsides over course of treatment; increase in cholesterol and triglyceride elevations; priapism (abnormal, painful, and continued swelling of the penis).
  • Sunlight and heat sensitivity may be increased. Take care to avoid dehydration.
  • Possibility of a suicide attempt exists in any person with schizophrenia. Close supervision and prescriptions in small amounts should accompany drug therapy to reduce risk of overdose.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Seroquel side effects, please contact your healthcare provider