Generic name: Tiludronate.

Skelid is a bisphosphonate. Bisphosphonates are a group of drugs used to treat a variety of conditions that cause bone mass to be reabsorbed by the body, including osteoporosis. Skelid slows down the loss of bone tissue and increases bone mass.

Quick Facts About Skelid


May have same uses as other bisphosphonates, but currently approved to treat Paget’s disease (a painful weakening of the bones).

Skelid Dosage

Take with a full glass of water in the morning, at least 30 to 60 minutes before the first food, beverage, or other medication; best absorbed if you wait longer. Do not lie down for at least 30 minutes after taking medication.

  • Usual adult dose: 400 milligrams once per day for 3 months.
  • Usual child dose: not prescribed for children.
  • Missed dose: take as soon as possible on an empty  stomach. Wait at least 2 hours after eating and at least 30 minutes after taking Skelid to take any other medication or food. If almost time for next dose, do not take missed dose; go back to regular schedule. Do not double doses.

Skelid Side Effects

Overdose symptoms:

none reported; however, very low blood calcium is likely. If you suspect an overdose, immediately seek medical attention.

More common side effects: diarrhea, dizziness, nausea, “pins and needles in hands and feet, upper respiratory infection (fluid in lungs, runny nose, sinus inflammation), upset stomach.

Less common Skelid side effects: aches and pains, cataracts, coughing, flushing, gas, glaucoma, infection, muscle aches, rash, red eyes, skin problems, swelling, tooth problems, vitamin D deficiency. Rare side effects: abdominal pain, appetite loss, constipation, high blood pressure, insomnia, tiredness, urinary tract infection.


Inform your doctor before combining Skelid with:

aspirin or indomethacin (Indocin). Wait at least 2 hours after taking Skelid to take any other medication.

Wait at least 2 hours after taking Skelid to take: antacids; calcium supplements; vitamin supplements.

Special Cautions

Not recommended for, and normally not used in, premenopausal women. However, if pregnant or planning to become pregnant, or breastfeeding, inform your doctor immediately.

No special precautions apply to seniors.

Not prescribed for children.

  • In order for Skelid to be effective, you must take the tablets without food, other beverages, or other medications.
  • Your doctor may recommend taking calcium or vitamin D supplements if you have low blood levels of calcium (hypocalcemia) or vitamin D deficiency.
  • Weight-bearing exercise can contribute to strengthening bones.
  • Inform your doctor before taking if you have kidney problems.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Skelid side effects, please contact your healthcare provider