Generic name: Trimipramine maleate.

Surmontil is a tricyclic antidepressant. It is thought to relieve depression by increasing the concentration of chemicals necessary for nerve transmissions in the brain.

Quick Facts About Surmontil


Used to treat depression.

Surmontil Dosage

May take in a single dose at bedtime or in smaller doses throughout the day. Continue taking medication as prescribed, even if there is no immediate effect. May take up to 4 weeks to observe results. If Surmontil is stopped suddenly, may experience nausea, headache, and general feeling of illness; follow doctor’s instructions on stopping medication.

  • Usual adult dose: 75 milligrams per day divided into smaller doses. Doctor may increase up to 150 milligrams per day divided into smaller doses. Single dose is recommended for long-term therapy; doses range from 50 to 150 milligrams per day. Seniors and adolescents — 50 milligrams per day, up to 100 milligrams per day, according to doctor’s instructions.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. If taking 1 dose per day at bedtime — do not take missed dose in the morning; may cause disturbing side effects during the day. Go back to regular schedule. Do not double doses.

Surmontil Side Effects

Overdose symptoms:

agitation, coma, convulsions, difficulty breathing, dilated pupils, discolored bluish skin, drowsiness, heart failure, high fever, involuntary movement, irregular heart rate, lack of coordination, low blood pressure, muscle rigidity, rapid heartbeat, restlessness, shock, stupor, sweating, vomiting. If you suspect an overdose, immediately seek medical attention.

Surmontil overdose can be fatal.

Side effects: abdominal cramps, agitation, anxiety, black tongue, blocked intestine, blood disorders, blurred vision, breast development in males, confusion (especially in seniors), constipation, delusions, diarrhea, difficulty urinating, dilated pupils, disorientation, dizziness, drowsiness, dry mouth, excessive or spontaneous milk flow, fatigue, fever, flushing, fluttery or throbbing heartbeat, frequent urination, hair loss, hallucinations, headache, heart attack, high blood pressure, high blood sugar, hives, impotence, increased or decreased sex drive, inflammation of the mouth, insomnia, irregular heart rate, lack of coordination, loss of appetite, low blood pressure, low blood sugar, nausea, nightmares, numbness, peculiar taste in mouth, purple or reddish-brown skin spots, rapid heartbeat, restlessness, ringing in the ears, seizures, sensitivity to light, skin itching, skin rash, sore throat, stomach upset, stroke, sweating, swelling of breasts, swelling of face and tongue, swelling of testicles, swollen glands, tingling or pins and needles, tremors, visual problems, vomiting, weakness, weight gain or loss, yellowing of skin and eyes.

No known less common or rare Surmontil side effects.


Do not start Surmontil for 2 weeks after taking MAO inhibitors such as Nardil and Parnate; may cause death.

Inform your doctor before combining Surmontil with:

antispasmodics such as Cogentin, cimetidine (Tagamet), guanethidine (Ismelin), local anesthetics, local decongestants such as Dristan Nasal Spray, oral nasal decongestants such as Sudafed, stimulants such as EpiPen, thyroid medications such as Synthroid.

Alcohol may cause extreme drowsiness and potentially serious side effects.

Special Cautions

Not known if Surmontil affects pregnancy or appears in breast milk. If pregnant or planning to become pregnant, inform your doctor immediately.

Seniors are prescribed lower doses.

Not generally prescribed for children.

  • May impair ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Avoid if you are recovering from a recent heart attack, or if sensitive to or allergic to this or similar medications such as Tofranil.
  • Use with caution if you have glaucoma, heart disease, liver disease, thyroid disease; are taking thyroid medication; or have problems urinating.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Surmontil side effects, please contact your healthcare provider