Generic name: Atenolol with chlorthalidone.

Tenoretic is a beta-adrenergic blocking agent (beta-blocker) and diuretic combination. Beta-blockers decrease the workload of the heart and help to regulate heartbeat. Diuretics lower blood pressure by helping the body produce and eliminate more urine. 

Quick Facts About Tenoretic


Used to treat high blood pressure. Combines a beta-blocker, which decreases the force and rate of heart contractions; and a diuretic, which makes the body produce and eliminate more urine, thereby lowering blood pressure. Can be used alone or with other high blood pressure medications.

Tenoretic Dosage

May take with or without food, per doctor’s instructions. Take exactly as prescribed, even if symptoms disappear. Try not to miss dose; condition may worsen if not taken regularly. Should not be stopped suddenly, for this can increase chest pain; dosage must be reduced gradually.

  • Usual adult dose: starting dose — one Tenoretic-50 tablet taken 1 time per day. Doctor may increase up to one Tenoretic-100 tablet taken 1 time per day. Dose is tailored to meet individual needs, and may be combined with other high blood pressure medications. For kidney disorder — dose will be adjusted accordingly.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless within 8 hours of next dose. In that case, do not take missed dose; go back to regular dose. Do not double doses.

Tenoretic Side Effects

Overdose symptoms:

no specific information available for Tenoretic. Symptoms of atenolol overdose: bronchospasm, congestive heart failure, low blood pressure, low blood sugar, slow heartbeat, sluggishness, wheezing. Symptoms of chlorthalidone component overdose: dizziness, nausea, weakness. If you suspect an overdose, immediately seek medical attention.

More common side effects: dizziness, fatigue, nausea, slow heartbeat.

Less common Tenoretic side effects: blood disorders, constipation, cramping, decreased sexual activity, depression, diarrhea, difficult or labored breathing, dizziness when getting up, drowsiness, excessive thirst hair loss, headache, high blood sugar, hives, impotence, light-headedness, loss of appetite, low potassium leading to symptoms like dry mouth, muscle pain or cramps, muscle spasm, Peyronie’s disease (deformity of the penis), psoriasis-like rash, rash, reddish or purplish spots on the skin, restlessness, skin sensitivity to light, sluggishness or unresponsiveness, stomach irritation, sugar in the urine, tingling or pins and needles, tiredness, vertigo, visual disturbances, vomiting, weak or irregular heartbeat, weakness, worsening of psoriasis, yellow eyes and skin.


Inform your doctor before combining Tenoretic with:

blood pressure medicines containing reserpine; clonidine (Catapres); epinephrine (EpiPen); insulin; lithium (Eskalith); nasal decongestants; other blood pressure drugs.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May cause harm to a developing fetus. Appears in breast milk; could affect a nursing infant.

Seniors with reduced kidney function may be prescribed a lower dosage.

Not generally prescribed for children.

  • Do not take if you have: heart block (conduction disorder); heart failure; inability to urinate; inadequate blood supply to the circulatory system (cardiogenic shock); sensitivity for allergic reaction to atenolol or chlorthalidone or similar drugs, or other sulfur drugs; slow heartbeat.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Can cause heartbeat to become too slow.
  • Use with caution with: asthma, coronary artery disease, kidney disease, history of severe congestive heart failure, seasonal allergies, or other bronchial conditions.
  • May mask the symptoms of low blood sugar or alter blood sugar levels.
  • Notify your doctor or dentist in a medical emergency or before surgery.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Tenoretic side effects, please contact your healthcare provider