Generic name: Tolmetin sodium.

Other brand names: Tolectin DS, Tolectin 200, Tolectin 600.

Tolectin is a nonsteroidal anti-inflammatory drug. It works by blocking the production of prostaglandins, which may trigger pain.

Quick Facts About Tolectin


Used to treat the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis. Used for acute episodes and long-term treatment. Also used to treat juvenile rheumatoid arthritis.

Tolectin Dosage

Take with food if you experience stomach irritation. Lying down for 20 to 30 minutes after taking medication may alleviate upset stomach.

  • Usual adult dose: 1,200 milligrams divided into 3 doses of 400 milligrams each, taken in the morning, afternoon, and at bedtime. Doctor may adjust dose after 1 to 2 weeks. Dosage range — 600 to 1,800 milligrams per day divided into 3 doses.
  • Usual child dose: 20 milligrams per 2.2 pounds of body weight per day, divided into 3 or 4 smaller doses. Dosage range — 15 to 30 milligrams per 2.2 pounds of body weight per day. Not generally prescribed for children under 2 years.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Tolectin Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

More common side effects: abdominal pain, change in weight, diarrhea, dizziness, gas, headache, heart-, burn, high blood pressure, indigestion, nausea, stomach and intestinal upset, swelling due to fluid retention, vomiting, weakness.

Less common or rare Tolectin side effects: anemia, blood in urine, chest pain, congestive heart failure, constipation, depression, drowsiness, fever, hepatitis, hives, inflammation of the mouth or tongue, kidney failure, painful urination, peptic ulcer, purple or reddish skin spots, ringing in the ears, severe allergic reactions, ] skin irritation, stomach inflammation, stomach or intestinal bleeding, urinary tract infection, visual disturbances, yellow eyes and skin.


Inform your doctor before combining Tolectin with:

aspirin, blood thinners such as Coumadin, carteolol (Cartrol), diuretics such as Lasix, glyburide (Micronase), lithium (Lithonate), methotrexate.

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk: could affect a nursing infant

Seniors are susceptible to kidney problems while taking Tolectin.

Follow doctor’s instructions carefully for children.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Ulcers or internal bleeding may occur suddenly; doctor should do frequent check-ups if you take Tolectin regularly.
  • Use with caution if you have heart disease or high blood pressure, Tolectin can increase water retention.
  • Avoid if sensitive to or allergic to other NSAIDs or if you have had asthma, hives, or nasal inflammation caused by aspirin or other NSAIDs.
  • May cause kidney problems if you have heart failure or liver disease, or take diuretics.
  • If you develop symptoms of liver problems such as yellow skin and eyes, notify your doctor. Doctor will discontinue Tolectin.
  • Contact your doctor if you experience visual disturbances.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Tolectin side effects, please contact your healthcare provider