Generic name: Clorazepate dipotassium.

Other brand names: Tranxene-SD, Tranxene-SD Half Strength.

Tranxene is a benzodiazepine tranquilizer. It reduces the activity of certain chemicals in the brain.

Quick Facts About Tranxene


Used to treat anxiety disorders and for short-term relief of anxiety.

Tranxene Dosage

Take exactly as prescribed. Follow doctor’s instructions for stopping medication; otherwise may experience withdrawal. Never change dose unless directed by your doctor.

  • Usual adult dose: for anxiety — Tranxene — 30 milligrams divided into several smaller doses. Doses range from 15 to 60 milligrams. Can also take in a single dose at bedtime, starting at 15 milligrams, and adjusted by your doctor. Tranxene-SD — one 22.5 milligram tablet every 24 hours. Not for initial dosing. Tranxene-SD Half Strength — one 11.25 milligram tablet every 24 hours. Not for initial dosing. For anxiety associated with depression — prescribed lower dose. For acute alcohol withdrawal — 30 milligrams per day to start, increased by doctor to 90 milligrams per day after 2 days; then dose is reduced and continually reduced gradually. Should be used under strict supervision by your doctor for alcohol withdrawal. When used with anti-epileptic medications — 7.5: milligrams taken 3 times per day. Doctor may increase by 7.5 milligrams per weekto a maximum of 90 milligrams per day. Seniors — 7.5 to 15 milligrams per day for anxiety.
  • Usual child dose: when used with anti-epileptic medications — children over 12 years — 7.5 milligrams taken 3 times per day. Doctor may increase by 7.5 milligrams per week to a maximum of 90 milligrams per day. For children 9 to 12 years — 7.5 milligrams taken 3 times per day. Doctor may increase by 7.5 milligrams per week to a maximum of 60 milligrams per day.
  • Missed dose: take as soon as possible, if within one hour of missed dose. Otherwise, do not take missed dose, go back to regular schedule. Do not double doses.

Tranxene Side Effects

Overdose symptoms:

coma, low blood pressure, sedation. If you suspect an overdose, immediately seek medical attention.

Most common side effect: drowsiness.

Less common or rare Tranxene side effects: blurred vision, depression, difficulty sleeping or falling asleep, dizziness, dry mouth, double vision, fatigue, genital and urinary tract disorders, headache, irritability, lack of muscle coordination, mental confusion, nervousness, tremors, skin rashes, slurred speech, stomach and intestinal disorders, tremor, aide effects due to abruptly stopping Tranxene: diarrhea, difficulty sleeping or falling asleep, hallucinations, impaired memory, irritability, muscle aches, nervousness, tremors.


Inform your doctor before combining Tranxene with:

barbiturates such as Nembutal and Seconal, MAO inhibitors such as Nardil and Parnate, major tranquilizers such as Mellaril and Thorazine, narcotic pain relievers such as Demerol and Percodan.

Do not drink alcohol during Tranxene therapy. 

Special Cautions

Increased risk of birth defects with benzodiazepine tranquilizers; avoid use during pregnancy. May appear in breast milk; could affect a nursing infant.

Seniors are prescribed lower doses, at risk for becoming unsteady or oversedated.

Follow doctor’s instructions carefully for children over 12 years.

  • Do not take if you have narrow-angle glaucoma.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Avoid if sensitive to or allergic to Tranxene.
  • Not prescribed for anxiety or tension related to everyday stress, or for serious conditions such as depression or severe psychological disorders.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Tranxene side effects, please contact your healthcare provider