Generic ingredients: Amitriptyline hydrochloride with perphenazine.

Other brand name: Etrafon.

Triavil is a tricyclic antidepressant and tranquilizer combination. Tricyclic antidepressants are thought to relieve depression by increasing the concentration of the chemicals necessary for nerve transmission to the brain, and tranquilizers reduce the activity of certain chemicals in the brain. 

Quick Facts About Triavil


Used to treat anxiety, agitation, and depression. Also used to treat people with schizophrenia who are depressed and people with insomnia, fatigue, loss of interest, loss of appetite, or a slowing of physical and mental reactions.

Triavil Dosage

May take with or without food. Follow doctor’s instructions for stopping Triavil to avoid withdrawal symptoms.

  • Usual adult dose:  no more than 4 tablets of Triavil 4-50 or 8 tablets of any other strength per day. May take several days to weeks to see improvement. For nonpsychotic anxiety and depression — 1 tablet of Triavil 2-25 or 4-25 taken 3 or 4 times per day, or 1 tablet of Triavil 4-50 taken twice per day. For anxiety in people with schizophrenia — 2 tablets of Triavil 4-25 taken 3 times per day. Doctor may advise taking another Triavil 4-25 tablet at bedtime if needed. For ongoing use — 1 tablet of Triavil 2-25 or 4-25 taken 2 to 4 times per day, or 1 tablet of Triavil 4-50 taken twice per day. Seniors and adolescents — 1 tablet of Triavil 4-10 taken 3 or 4 times per day.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless within 2 hours of next dose. In that case, do not take missed dose, go back to regular schedule. Do not double doses.

Triavil Side Effects

Overdose symptoms:

Overdose symptoms: abnormalities of posture and movements, agitation, coma, convulsions, dilated pupils, drowsiness, extremely low body temperature, eye movement problems, high fever, heart failure, overactive reflexes, rapid or irregular heartbeat, rigid muscles, stupor, very low blood pressure, vomiting. If you suspect an overdose, immediately seek medical attention.

Triavil overdose may be fatal.

Side effects: abnormal milk secretions; abnormalities of movements and posture; anxiety; asthma; black tongue; blood disorders; blurred vision; bodily rigidity, arched backward; breast development in males; change in pulse rate; chewing movements; coma; confusion; constipation; convulsions; delusions; diarrhea; difficulty breathing; difficulty concentrating; difficulty swallowing; dilated pupils; disorientation; dizziness; drowsiness; dry mouth; eating abnormal amounts of food; ejaculation failure; episodes of elation or irritability; excessive or spontaneous flow of milk; excitement; exhaustion; eye problems; eye spasms; eyes in a fixed position; fatigue; fever; fluid accumulation and swelling (throat and brain, face and tongue, arms and legs); frequent urination; hair loss; hallucinations; headache; heart attacks; hepatitis; high fever; high or low blood pressure; hives; impotence; inability to stop moving; inability to urinate; increased or decreased sex drive; inflammation of the mouth; insomnia; intestinal blockage; intolerance to light; involuntary jerky movements of the tongue, face, mouth, lips, jaw, body, or arms and legs; irregular blood pressure, pulse, and heartbeat; irregular menstrual periods; lack of coordination; light-headedness upon standing; liver problems; lockjaw; loss or increase of appetite; low blood pressure; muscle stiffness; nasal congestion; nausea; nightmares; odd taste in mouth; overactive reflexes; pain and stiffness around neck; palpitations; protruding tongue; puckering of the mouth; puffing of the cheeks; purple or reddish-brown spots on skin; rapid heartbeat; restlessness; rigid arms and feet, head, and muscles; ringing in the ears; salivation; sedation; seizures; sensitivity to light; severe allergic reactions; skin rash or inflammation; scaling; spasms in the hands and feet; speech problems; stomach upset; stroke; sweating; swelling of breasts; swelling of testicles; swollen glands; tingling or pins and needles and numbness in hands and feet; tremors; twisted neck; twitching in the body, neck, shoulders, and face; uncontrollable and involuntary urination; urinary problems; visual problems; vomiting; weakness; weight gain or loss; writhing movements; yellowed skin and eyes.

No known less common or rare Triavil side effects.


Inform your doctor before combining Triavil with:

airway-opening medications such as Proventil; anticonvulsants such as Dilantin; antidepressant MAO inhibitors such as Nardil and Parnate; antihistamines such as Benadryl; antispasmodics such as Bentyl; atropine (Donnatal); barbiturates such as phenobarbital; blood thinners such as Coumadin; cimetidine (Tagamet); disulfiram (Antabuse); epinephrine (EpiPen); ethchlorvynol (Placidyl); fluoxetine (Prozac); furazolidone (Furoxone); guanethidine (Ismelin); major tranquilizers such as Haldol; narcotic analgesics such as Percocet; thyroid medications such as Synthroid. Narcotics, painkillers, and sleep medications may cause extreme drowsiness if used with Triavil.

Alcohol taken with Triavil can cause extreme drowsiness and other serious side effects. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May cause false-positive pregnancy test results. Not recommended for nursing mothers.

Seniors are prescribed a lower dose. Senior women at increased risk for tardive dyskinesia — involuntary muscle spasms and twitches in the face and body.

Not generally prescribed for children. Adolescents should follow doctor’s instructions carefully.

  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Inform your doctor before starting Triavil if you have or had: glaucoma; difficulty urinating; breast cancer; seizures; heart, liver, or thyroid disease; or if exposed to pesticides or extreme heat.
  • May mask symptoms of brain tumor, intestinal blockage, overdose of other medications.
  • At risk for tardive dyskinesia, condition marked by involuntary muscle spasms and twitches in the face and body.
  • Avoid if allergic to any of the ingredients of Triavil.
  • Should not use if you have recently had a heart attack or have an abnormal bone marrow condition.
  • Stop taking Triavil and inform your doctor if you develop a fever.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Triavil side effects, please contact your healthcare provider