Generic name: Choline magnesium trisalicylate.

Other brand name: Tricosal.

Trilisate is a non-narcotic analgesic anti-inflammatory. It reduces pain and inflammation.

Quick Facts About Trilisate


Used to treat symptoms of rheumatoid arthritis, osteoarthritis, and other forms of arthritis on a long-term basis. Also prescribed for acute painful shoulder; mild to moderate pain in general; fever; and juvenile rheumatoid arthritis.

Trilisate Dosage

Take exactly as prescribed. Comes in tablet or liquid form. May take 2 to 3 weeks to observe the effects of this medication.

  • Usual adult dose: for rheumatoid arthritis, osteoarthritis, more severe arthritis, and acute painful shoulder — 1,500 milligrams taken 2 times per day or 3,000 milligrams taken once per day. For mild to moderate pain or fever — 2,000 to 3,000 milligrams per day divided into 2 equal doses. Seniors — 2,250 milligrams per day divided into 3 doses of 750 milligrams. Liquid is prescribed for those who cannot swallow tablets.
  • Usual child dose: for inflammation or pain — children weighing 81 pounds or less — 50 milligrams per 2.2 pounds of body weight taken 2 times per day. Children weighing over 81 pounds — 2,250 milligrams per day divided into 2 doses. Liquid is prescribed for those who cannot swallow tablets.
  • Missed dose: if taking on a regular basis — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Trilisate Side Effects

Overdose symptoms:

confusion, diarrhea, dizziness, drowsiness, headache, hearing impairment, rapid breathing, ringing in ears, sweating, vomiting. If you suspect an overdose, immediately seek medical attention.

More common side effects: constipation, diarrhea, heartburn, indigestion, nausea, ringing in the ears, stomach pain and upset, vomiting.

Less common Trilisate side effects: dizziness, drowsiness, headache, hearing impairment, light-headedness, sluggishness. Rare side effects: asthma, blood in stool, bruising, confusion, distorted sense of taste, hallucinations, hearing loss, hepatitis, hives, inflammation of upper gastric tract, itching, loss of appetite, nosebleed, rash, skin eruptions or discoloration, stomach or intestinal ulcers, swelling due to fluid accumulation, weight gain.


Inform your doctor before combining Trilisate with:

antacids such as Gaviscon or Maalox; antigout medications; blood thinners such as Coumadin; Diamox; diabetes medications such as insulin, Micronase, and Tolinase; methotrexate; other salicylates such as aspirin; phenytoin (Dilantin); steroids such as prednisone; valproic acid (Depakene).

No known food/other substance interactions. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant.

Seniors are prescribed a lower dose.

Follow doctor’s instructions carefully for children. Should not be used by children or teenagers who have chicken pox or flu symptoms — increases risk of Reye’s syndrome (rare neurological disorder).

  • Inform your doctor before starting Trilisate if you have asthma and are allergic to aspirin. Avoid if sensitive to or allergic to Trilisate.
  • Use with caution if you have: severe or recurring kidney or liver disorder, gastritis (inflammation of stomach lining), or stomach or intestinal disorder.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Trilisate side effects, please contact your healthcare provider