Generic ingredients: Hydrocodone polistirex with chlorpheniramine polistirex.

Tussionex is a cough suppressant and antihistamine combination. It works by acting on the brain to suppress the cough reflex and blocks the action of histamine, a chemical the body produces during an allergic reaction.

Quick Facts About Tussionex


Used to relieve coughs and upper respiratory colds and allergies.

Tussionex Dosage

Take exactly as prescribed, not diluted with other liquids or medications. Shake well before using.

  • Usual adult dose: 1 teaspoonful (5 milliliters) every 12 hours; do not exceed more than 2 teaspoonfuls in 24 hours.
  • Usual child dose: for children ages 6 to 12 — 1/2 teaspoonful every 12 hours; do not exceed more than 1 teaspoonful in 24 hours. For children over 12 years — follow doctor’s instructions. Not generally prescribed for children under 6 years.
  • Missed dose: if taking on a regular schedule — take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Tussionex Side Effects

Overdose symptoms:

blue skin color due to lack of oxygen, cardiac arrest, cold and clammy skin, decreased or difficult breathing, extreme sleepiness leading to stupor or coma, low blood pressure, muscle flabbiness, slow heartbeat, temporary cessation of breathing. If you suspect an overdosej immediately seek medical attention.

Side effects: anxiety, constipation, decreased mental and physical performance, difficulty breathing, difficulty urinating, dizziness, drowsiness, dry throat, emotional dependence, exaggerated feeling of depression, exaggerated sense of well-being, extreme calm, fear, itching, mental clouding, mood changes, nausea, rash, restlessness, sluggishness, tightness in chest, vomiting.

No known less common or rare Tussionex side effects.


Inform your doctor before combining Tussionex with:

antidepressant MAO inhibitors such as Nardil and Parnate; antihistamines such as Benadryl; anti-spasmodic medications such as Bentyl and Cogentin; anxiety medications such as Xanax and Valium; depression medications such as Elavil and Prozac; major tranquilizers such as Thorazine and Compazine; narcotics such as Percocet and Demerol.

Do not drink alcohol when taking this medication. 

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant There may be a risk of physical dependence in infants born to mothers taking narcotics such as Tussionex.

Seniors should use with caution.

Follow doctor’s instructions carefully for children.

  • Do not take if sensitive to or allergic to any ingredients in Tussionex.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • May cause tolerance and dependence if used for several weeks, as it contains a mild narcotic.
  • Use with caution if you have lung disease or breathing disorder, may produce slowed or irregular breathing. Also use with caution if you have: narrow-angle glaucoma, asthma, enlarged prostate, urinary difficulties, intestinal disorder, liver or kidney disease, underactive thyroid gland, Addison’s disease (disorder of adrenal glands), or if you have recently had a head injury.
  • Can mask a severe abdominal condition or cause internal blockage.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Tussionex side effects, please contact your healthcare provider