Generic name: Sparfloxacin.

Zagam is a fluoroquinolone antibiotic/anti-infective. It is used to treat a variety of bacterial infections.

Quick Facts About Zagam


Used to treat acute chronic bronchitis and pneumonia.

Zagam Dosage

Take exactly as prescribed. Take with food if you experience dizziness or light-headedness. Use all of the prescribed dose; otherwise at risk for symptoms to return.

  • Usual adult dose: first day — 400 milligrams taken once. Maintenance dose — 200 milligrams once per day for 10 days. Doctor will prescribe lower dose if you have kidney failure.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Zagam Side Effects

Overdose symptoms:

convulsions, difficulty lifting eyelids, loss of muscular control, slowing in activity and breathing, tremors. If you suspect an overdose, immediately seek medical attention.

More common side effects: unusual sensitivity to light.

Less common Zagam side effects: abdominal pain, diarrhea, dizziness, headache, nausea, vomiting. Rare side effects: abnormal blood platelet, sugar, or leukocyte levels, abnormal coordination, abnormal liver function, agitation, allergy and allergic shock, amnesia, anemia, angina, anorexia, anxiety, asthma, back or chest pain, bilirubinemia, blood clots, brain tumor, chills, cold clammy skin, confusion, constipation, convulsions, decreased sensitivity to touch, depersonalization, depression, difficulty concentrating, difficulty speaking or swallowing, dizziness or lightheadedness when rising from a sitting or lying position, dry mouth, eye pain, fatigue, fever, flushing, gas, gingivitis, hallucination, heart palpitation, hemorrhaging, hiccups, hot flashes, hypertension, hypertonia, increased appetite, increased saliva or sweating, infection, involuntary muscle contractions, insomnia, intestinal inflammation, irregular heartbeat, itching, jaundice, joint pain, kidney disorders, loose or discolored stool, low blood pressure, muscle cramps or weakness, menstrual disorder in women, migraine, “pins and needles” in hands and feet, rash, reduced sex drive or impotence in men, skeletal pain, skin disorders, swelling, taste changes, tendonitis, thirst, tiredness, tongue paralysis, tooth disorder, tremor, unusual walking, unusual dreams or thoughts, upset stomach, upper respiratory tract infection, urinary problems, vaginitis, vision problems, weakness, weight changes.


Inform your doctor before combining Zagam with:

anticonvulsants such as carbamazepine (Tegretol) and phenytoin (Dilantin); antiarrhythmic drugs such as quinidine (Quinalan), procainamide (Procan), timolol (Blocadren), and bepridil (Vascor); benzodiapines such as diazepam (Valium); terfenadine (Seldane).

Antacids and vitamins or minerals containing iron should be taken at least 2 hours before or after Zagam dose. Avoid alcohol and over-the-counter cough suppressants containing dextromethorphan.

Special Cautions

If pregnant or planning to become pregnant, inform your doctor immediately. Appears in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children.

  • Has caused severe or fatal reactions, sometimes after first dose. If you develop any of the following symptoms, immediately seek medical help: confusion, convulsions, depression, difficulty breathing, hallucinations, hives, insomnia, itching light-headedness, loss of consciousness, paranoia, rash, restlessness, swelling in face or throat, tingling tremors.
  • Inform your doctor if you have experienced diarrhea when taking other antibacterial medications, or develop diarrhea at the start of Zagam therapy. May cause bowel inflammation (colitis), which could be life-threatening.
  • Use with caution if you have: epilepsy, severe hardening of the arteries in the brain, or other seizure-inducing conditions; or kidney failure or problems.
  • Avoid exposure to sunlight.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • Discontinue treatment and inform your doctor immediately if you experience pain, inflammation, or rupture of a tendon.
  • Should not take if sensitive or allergic to Zagam or other quinolone antibiotics such as Cipro and Floxin.

Note: provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Zagam side effects, please contact your healthcare provider