Generic name: Lisinopril with hydrochlorothiazide.

Other brand name: Prinzide.

Zestoretic is an angiotensin-converting enzyme (ACE) inhibitor/antihypertensive and a diuretic. It works to reduce blood pressure by preventing angiotensin I from converting into a more potent enzyme that increases salt and water retention; and it reduces fluid accumulation in the body.

Quick Facts About Zestoretic


Used to treat high blood pressure.

Zestoretic Dosage

May take with or without food. Must take regularly for it to be effective. May take several weeks to observe the effects of Zestoretic. Continue to take even when symptoms disappear.

  • Usual adult dose: 1 or 2 tablets taken once per day, once blood pressure is stable. If possible, discontinue diuretics before taking Zestoretic, or if it is not possible, doctor may give initial dose and supervise further doses. Doses are individualized.
  • Usual child dose: not generally prescribed for children.
  • Missed dose: take as soon as possible, unless it is the  next day. In that case, do not take the missed dose; go back to regular schedule. Do not double doses.

Zestoretic Side Effects

Overdose symptoms:

dehydration, low blood pressure. If you suspect an overdose, immediately seek medical attention.

More common side effects: cough, dizziness, fatigue, headache.

Less common Zestoretic side effects: diarrhea; impotence; indigestion; low blood pressure; muscle cramps; nausea; rash; tingling or pins and needles; upper respiratory infection; vomiting; weakness. Rare side effects: abdominal pain; anemia; arthritis; back pain; back strain; blurred vision; bronchitis; bruising; chest discomfort; chest pain; common cold; confusion; constipation; decreased sex drive; depression; difficulty breathing; difficulty falling or staying asleep; dry mouth; earache; excessive perspiration; fainting; fever; flu; flushing; foot pain; gas; general feeling of illness; gout; hay fever; heart attack; heartburn; heart rhythm disturbances; hepatitis; hives; itching; joint pain; kidney failure; knee pain; loss of appetite; low blood pressure; lung congestion; muscle pain; muscle spasm; nervousness; palpitations; rapid heartbeat; red or purple skin spots; reduced urine output; restlessness; ringing in ears; sensitivity to light; shortness of breath; severe allergic reaction; shoulder pain; sinus inflammation; skin inflammation; sleepiness; sore throat; stomach and intestinal cramps; stroke; stuffy nose; swelling of the face, lips, tongue, throat, or arms and legs; trauma; urinary tract infection; vertigo; virus infection; vision abnormality in which objects have yellowish hue; yellow eyes and skin.


Inform your doctor before combining Zestoretic with:

barbiturates such as Nembutal and Seconal, corticosteroids such as prednisone, high blood pressure medications such as Procardia and Aldomet, indomethacin (Indocin), insulin, lithium (Lithonate), muscle relaxants such as Tubocurarine, narcotics such as Darvon and Dilaudid, nonsteroidal antiinflammatory medications such as Naprosyn, oral antidiabetic medications such as Micronase, potassium supplements such as Slow-K, potassium-sparing diuretics such as Midamor.

Avoid alcohol while taking Zestoretic. Do not use potassium containing salt substitutes unless directed by your doctor.

Special Cautions

Can cause birth defects, premature births, or death in the fetus and newborn if taken during the second and third trimesters. If pregnant or plan to become pregnant, inform your doctor immediately. May appear in breast milk; could affect a nursing infant

No special precautions apply to seniors.

Not generally prescribed for children.

  • Inform your doctor before starting Zestoretic if you have: congestive heart failure, diabetes, liver disease, history of allergy or bronchial asthma, or lupus erythematosus.
  • Not recommended for individuals on dialysis.
  • Avoid if sensitive to or allergic to any of the ingredients in Zestoretic or other ACE inhibitor or sulfonamide-derived medications; if previous ACE inhibitor treatment resulted in angioedema (swelling of face, lips, tongue, throat arms, or legs); or if you are unable to urinate. If you experience angioedema, it may require emergency treatment.
  • If you experience light-headedness or faint, stop taking and contact your doctor.
  • Fluid depletion (caused by dehydration, excessive sweating, severe diarrhea, or vomiting) may cause dangerously low blood pressure.
  • Immediately notify your doctor if you experience chest pain, sore throat, or fever and chills.
  • Doctor will monitor blood sugar levels if you are diabetic.
  • Notify your doctor or dentist prior to surgery that you are taking Zestoretic.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Zestoretic side effects, please contact your healthcare provider