Generic name: Zyloprim.

Other brand names: Lopurin, Zurinol.

Zyloprim is an antigout medication. It blocks the production of uric acid in the body.

Quick Facts About Zyloprim


Used to treat gout. Also used to treat cancer and other conditions associated with too much uric acid in the body, and to manage some types of kidney stones.

Zyloprim Dosage

To avoid stomach irritation, take with food, a full glass of water or milk. May take 2 to 6 weeks before full effects are observed. To prevent kidney stones, drink 10 to 12 glasses of fluids per day, unless otherwise prescribed by your doctor.

  • Usual adult dose: for gout — 100 milligrams taken once per day. Doctor may increase by 100 milligrams per day at 1-week intervals. Average dose for mild gout — 200 to 300 milligrams. For moderate to severe gout — 400 to 600 milligrams. Maximum daily dose — 800 milligrams. For recurrent kidney stones — 200 to 300 milligrams per day divided into smaller doses or taken as a single dose. For management of uric acid levels in certain cancers — 600 to 800 milligrams per day for 2 to 3 days, with a high fluid intake.
  • Usual child dose: for children 6 to 10 years — 300 milligrams per day to manage uric acid levels in certain types of cancer. For children under 6 years — 150 milligrams per day.
  • Missed dose: take as soon as possible, unless almost time for next dose. In that case, do not take missed dose; go back to regular schedule. Do not double doses.

Zyloprim Side Effects

Overdose symptoms:

no specific information available. If you suspect an overdose, immediately seek medical attention.

Most common side effect is skin rash. If you develop a rash, stop taking Zyloprim and call your doctor. Rash may be itchy or scaly, or skin may peel off in sheets; rash may be accompanied by chills and fever, aching joints, or jaundice.

More common side effects: acute attack of gout, diarrhea, nausea, rash.

Less common Zyloprim side effects: abdominal pain; bruising; chills; fever; hair loss; headache; hepatitis; hives; indigestion; itching; joint pain; kidney failure; lack of ability to concentrate; loosening of nails; muscle disease; nosebleed; numbness; rare skin condition characterized by severe blisters and bleeding on the lips, eyes or nose; reddish-brown or purplish spots on the skin; skin inflammation or peeling; sleepiness; stomach inflammation; taste loss or change; tingling or pins and needles; unusual bleeding; vomiting; yellowing of skin and eyes.


Inform your doctor before combining Zyloprim with:

amoxicillin (Amoxil or Polymox); ampicillin (Omnipen or Polycillin); azathioprine (Imuran); blood thinners such as Coumadin; drugs for diabetes such as Diabinese and Orinase; mercaptopurine (Purinethol); probenecid (Benemid or ColBEN-EMID); sulfinpyrazone (Anturane); theophylline (Theo-Dur or Slo-Phyllin); thiazide diuretics such as HydroDIURIL. Avoid taking large doses of vitamin C.

Avoid alcohol, beer, wine, and purine-rich foods such as anchovies, sardines, liver, kidneys, lentils, and sweetbreads when taking Zyloprim.

Special Cautions

If pregnant or planning to become pregnant, notify your doctor immediately. May cause birth defects or interfere with baby’s development. Caution — Zyloprim appears in breast milk.

No special precautions apply to seniors.

Follow doctor’s instructions carefully for children.

  • If you develop a skin rash or other allergic reactions, stop taking Zyloprim and immediately contact your doctor. In some people, a Zyloprim-induced rash may lead to serious skin disease, generalized inflammation of a blood or lymph vessel, irreversible liver damage, or death.
  • May cause drowsiness and impair your ability to drive a car or operate machinery. Do not take part in any activity that requires alertness.
  • In the early stages of taking Zyloprim, you may experience attacks of gout. Attacks will decrease after several months of therapy.
  • If you have a kidney problem, high blood pressure or diabetes, your doctor should prescribe Zyloprim carefully and periodically monitor your kidney function.


HealthSurvey.org provides accurate and independent information prescription pills, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you have questions about  dosage, or Zyloprim side effects, please contact your healthcare provider